教員紹介【斉藤伸一准教授】

トップ
学部学科・専攻
教員紹介
教員紹介【斉藤伸一准教授】

教員名	斉藤　伸一　（さいとう　しんいち）
職名	准教授
学歴	筑波大学大学院生命環境科学研究科情報生物科学専攻単位取得満期退学
学位	博士（理学）
担当教科	総合基礎演習Ⅰ 総合基礎演習Ⅱ 自然科学Ⅱ（化学）現代家政学演習Ⅱ 食の科学Ⅱ（食品学）解剖・生理学実験食品学Ⅰ 食品学Ⅱ 食品衛生学食品衛生学実験
専攻・専門分野	分子生物学、病態生理学
研究テーマ・内容	腸内細菌の代謝産物が病態に及ぼす影響の研究＼こういう研究・授業をしています／主に「食品学」の授業を担当しています。研究対象としては「腸内細菌」に興味があります。いわゆる悪玉細菌が病気の発生や進行に影響することはよく知られていますが、まだまだ分からないことも多いため、食品ー腸内細菌ー病気の関係性の解明に寄与したいと考えています。
所属学会	日本癌学会、日本腎臓学会
学外活動
研究業績：著書
研究業績：論文	・Saito S, Koya Y, Kajiyama H, Yamashita M, Nawa A. Indoxyl sulfate promotes metastatic characteristics of ovarian cancer cells via aryl hydrocarbon receptor-mediated downregulation of the Mas receptor. Laboratory Investigation 103(3): 100025, 2023. ・Saito S, Koya Y, Kajiyama H, Yamashita M, Kikkawa F, Nawa A. Folate-appended cyclodextrin carrier targets ovarian cancer cells expressing proton-coupled folate transporter. Cancer Science 111(5): 1794-1804, 2020. ・Tomabechi Y, Tsuruta T, Saito S, Wabitsch M, Sonoyama K. Extra-adrenal glucocorticoids contribute to the postprandial increase of circulating leptin in mice. Journal of Cell Communication and Signaling 12(2): 433-439, 2018. ・Aoki-Yoshida A, Saito S, Tsuruta T, Ohsumi A, Tsunoda H, Sonoyama K. (These authors contributed equally to this work.) Exosomes isolated from sera of mice fed Lactobacillus strains affect inflammatory cytokine production in macrophages in vitro. Biochemical and Biophysical Research Communications 489(2): 248-254, 2017. ・Nakayama K, Saito S, Watanabe K, Miyashita H, Nishijima F, Ishizuka S, Niwa T, Iwamoto S, Shimizu H. (These authors contributed equally to this work.) Associations between an AHRR polymorphism and estimated glomerular filtration rate, serum creatinine and hemoglobin levels. Bioscience, Biotechnology, & Biochemistry 81(6): 1120-1124, 2017. ・Ng HY, Bolati W, Lee CT, Chien YS, Yisireyili M, Saito S, Pei SN, Nishijima F, Niwa T. Indoxyl sulfate downregulates Mas receptor via aryl hydrocarbon receptor/nuclear factor-kappa B, and induces cell proliferation and tissue factor expression in vascular smooth muscle cells. Nephron 133(3): 205-212, 2016. ・Tsuruta T, Saito S, Osaki Y, Hamada A, Aoki-Yoshida A, Sonoyama K. (These authors contributed equally to this work.) Organoids as an ex vivo model for studying the serotonin system in the murine small intestine and colon epithelium. Biochemical and Biophysical Research Communications 474(1): 161-167, 2016. ・Aoki-Yoshida A, Saito S, Fukiya S, Aoki R, Takayama Y, Suzuki C, Sonoyama K. (These authors contributed equally to this work.) Lactobacillus rhamnosus GG increases Toll-like receptor 3 gene expression in murine small intestine ex vivo and in vivo. Beneficial Microbes 7(3): 421-429, 2016. ・Saito S, Yisireyili M, Shimizu H, Ng HY, Niwa T. Indoxyl sulfate upregulates prorenin expression via nuclear factor-κB p65, signal transducer and activator of transcription 3, and reactive oxygen species in proximal tubular cells. Journal of Renal Nutrition 25(2): 145-148, 2015. ・Adelibieke Y, Yisireyili M, Ng HY, Saito S, Nishijima F, Niwa T. Indoxyl sulfate induces IL-6 expression in vascular endothelial and smooth muscle cells through OAT3-mediated uptake and activation of AhR/NF-κB pathway. Nephron Experimental Nephrology 128(1-2): 1-8, 2014. ・Yisireyili M, Saito S, Abudureyimu S, Adelibieke Y, Ng HY, Nishijima F, Takeshita K, Murohara T, Niwa T. Indoxyl sulfate-induced activation of (pro)renin receptor promotes cell proliferation and tissue factor expression in vascular smooth muscle cells. PLoS One 9(10): e109268, 2014. ・Ng HY, Yisireyili M, Saito S, Lee CT, Adelibieke Y, Nishijima F, Niwa T. Indoxyl sulfate downregulates expression of Mas receptor via OAT3/AhR/Stat3 pathway in proximal tubular cells. PLoS One 9(3): e91517, 2014. ・Saito S, Shimizu H, Yisireyili M, Nishijima F, Enomoto A, Niwa T. (*These authors contributed equally to this work.) Indoxyl sulfate-induced activation of (pro)renin receptor is involved in expression of TGF-β1 and α-smooth muscle actin in proximal tubular cells. Endocrinology 155(5): 1899-1907, 2014. ・Yisireyili M, Shimizu H, Saito S, Enomoto A, Nishijima F, Niwa T. Indoxyl sulfate promotes cardiac fibrosis with enhanced oxidative stress in hypertensive rats. Life Sciences 92(24-26): 1180-1185, 2013. ・Kawashima D, Kanda T, Murata T, Saito S, Sugimoto A, Narita Y, Tsurumi T. Nuclear transport of Epstein-Barr virus DNA polymerase is dependent on the BMRF1 polymerase processivity factor and molecular chaperone Hsp90. Journal of Virology 87(11): 6482-6491, 2013. ・Shimizu H, Saito S, Higashiyama Y, Nishijima F, Niwa T. CREB, NF-κB, and NADPH oxidase coordinately upregulate indoxyl sulfate-induced angiotensinogen expression in proximal tubular cells. American Journal of Physiology Cell Physiology 304(7): C685-C692, 2013. ・Adelibieke Y, Shimizu H, Saito S, Mironova R, Niwa T. Indoxyl sulfate counteracts endothelial effects of erythropoietin through suppression of Akt phosphorylation. Circulation Journal 77(5): 1326-1336, 2013. ・Saito S, Murata T, Kanda T, Isomura H, Narita Y, Sugimoto A, Kawashima D, Tsurumi T. Epstein-Barr virus deubiquitinase downregulates TRAF6-mediated NF-κB signaling during productive replication. Journal of Virology 87(7): 4060-4070, 2013. ・Murata T, Kondo Y, Sugimoto A, Kawashima D, Saito S, Isomura H, Kanda T, Tsurumi T. Epigenetic histone modification of Epstein-Barr virus BZLF1 promoter during latency and reactivation in Raji cells. Journal of Virology 86(9): 4752-4761, 2012. ・Noda C, Murata T, Kanda T, Yoshiyama H, Sugimoto A, Kawashima D, Saito S, Isomura H, Tsurumi T. Identification and characterization of CCAAT enhancer-binding protein (C/EBP) as a transcriptional activator for Epstein-Barr virus oncogene latent membrane protein 1. Journal of Biological Chemistry 286(49): 42524-42533, 2011. ・Murata T, Noda C, Saito S, Kawashima D, Sugimoto A, Isomura H, Kanda T, Yokoyama K, Tsurumi T. Involvement of Jun dimerization protein 2 (JDP2) in the maintenance of Epstein-Barr virus latency. Journal of Biological Chemistry 286(25): 22007-22016, 2011. ・Sugimoto A, Kanda T, Yamashita Y, Murata T, Saito S, Kawashima D, Isomura H, Nishiyama Y, Tsurumi T. Spatiotemporally different DNA repair systems participate in Epstein-Barr virus genome maturation. Journal of Virology 85(13): 6127-6135, 2011. ・Saito S, Kobayashi M, Kimoto-Nira H, Aoki R, Mizumachi K, Miyata S, Yamamoto K, Kitagawa Y, Suzuki C. Intraspecies discrimination of Lactobacillus paraplantarum by PCR. FEMS Microbiology Letters 316(1): 70-76, 2011. ・Saito S, Takayama Y, Mizumachi K, Suzuki C. Lactoferrin promotes hyaluronan synthesis in human dermal fibroblasts. Biotechnology Letters 33(1): 33-39, 2011. ・Saito S, Kakeshita H, Nakamura K. Novel small RNA-encoding genes in the intergenic regions of Bacillus subtilis. Gene 428(1-2): 2-8, 2009.
メッセージ	学生時代は『よく学び、よく遊べ』だと思います。色々な場所で色々なことを体験し、学んで、人間として成長していってくれたら嬉しいです。